Trnka L, Kvapilová M, Mison P
Chemotherapy. 1976;22(6):353-61. doi: 10.1159/000221947.
The influence of the host immunosuppression on antimycobacterial effects of isoniazid, rifampicin or streptomycin was studied on animal models. Differences in survival rates of mice influenced or uninfluenced by azathioprine (Imuran) and exposed to six applications of antituberculous drugs (given once a day in the monotherapy) were statistically evaluated. The dose-dependent antimycobacterial effects of rifampicin or isoniazid were not significantly altered by the immunosuppression of the host. In contrary to that definite dose-dependent effect of streptomycin, observed in azathioprine-uninfluenced mice, cannot be confirmed in immunosuppressed mice in which no effect of streptomycin on the survival of tuberculous mice could be estimated.
在动物模型上研究了宿主免疫抑制对异烟肼、利福平或链霉素抗分枝杆菌作用的影响。对受硫唑嘌呤（依木兰）影响或未受影响且接受六种抗结核药物治疗（单药治疗时每天给药一次）的小鼠存活率差异进行了统计学评估。宿主免疫抑制并未显著改变利福平或异烟肼的剂量依赖性抗分枝杆菌作用。与链霉素在未受硫唑嘌呤影响的小鼠中观察到的明确剂量依赖性作用相反，在免疫抑制的小鼠中无法证实链霉素对结核小鼠存活率有影响，无法评估链霉素的作用。
