Bakker-Woudenberg I A, de Jong-Hoenderop J Y, Michel M F
Infect Immun. 1979 Jul;25(1):366-75. doi: 10.1128/iai.25.1.366-375.1979.
The importance of intact host defense mechanisms for successful antimicrobial therapy was investigated in an animal model. Recovery from lobar pneumococcal pneumonia as a result of penicillin therapy was studied in normal rats and in rats treated with cobra venom factor. This factor was used to selectively suppress the phagocytosis of pneumococci as a result of complement depletion. Although complete recovery from the infection occurred in normal rats after appropriate penicillin therapy, this was not the case in cobra venom factor-treated rats. Within the limitations of this study, evidence is presented for loss of antibiotic activity as a consequence of impaired phagocytosis.
在一个动物模型中，研究了完整的宿主防御机制对于成功进行抗菌治疗的重要性。在正常大鼠和用眼镜蛇毒因子处理的大鼠中，研究了青霉素治疗导致大叶性肺炎球菌肺炎恢复的情况。该因子用于通过补体耗竭选择性抑制肺炎球菌的吞噬作用。虽然在适当的青霉素治疗后正常大鼠从感染中完全恢复，但在眼镜蛇毒因子处理的大鼠中并非如此。在本研究的局限性范围内，有证据表明吞噬作用受损会导致抗生素活性丧失。
