Synthesis and antimicrobial evaluation of TAN-1057A/B analogs.
作者信息
Williams R M, Yuan C, Lee V J, Chamberland S
机构信息
Department of Chemistry, Colorado State University, Fort Collins 80523, USA.
出版信息
J Antibiot (Tokyo). 1998 Feb;51(2):189-201. doi: 10.7164/antibiotics.51.189.
PMID:9544941
Abstract
TAN-1057A-D, dipeptides isolated from bacteria Flexibacter sp. PK-74 and PK-176, are new antibiotics with potent antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). We describe, in detail, the synthesis of several TAN-1057A/B analogs by a convergent route featuring a new method to construct the cyclic amidinourea functional group. The biological activity of these substances against methicillin-resistant Staphylococcus aureus (MRSA) is reported.
摘要
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