TAN-1057 A-D，对耐甲氧西林金黄色葡萄球菌具有强效抗菌活性的新型抗生素。分类学、发酵及生物活性。
TAN-1057 A-D, new antibiotics with potent antibacterial activity against methicillin-resistant Staphylococcus aureus. Taxonomy, fermentation and biological activity.
作者信息
Katayama N, Fukusumi S, Funabashi Y, Iwahi T, Ono H
机构信息
Discovery Research Laboratories II, Takeda Chemical Industries, Ltd., Osaka, Japan.
出版信息
J Antibiot (Tokyo). 1993 Apr;46(4):606-13. doi: 10.7164/antibiotics.46.606.
Two Gram-negative bacteria were found to produce the new antibacterial antibiotics TAN-1057 A, B, C and D. The producing bacteria were characterized and designated as Flexibacter sp. PK-74 and PK-176. These antibiotics were active against Gram-negative and Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus. TAN-1057 A inhibited protein biosynthesis in Escherichia coli and S. aureus. It showed excellent protective effects against an experimental methicillin-resistant S. aureus infection in mice.
发现两种革兰氏阴性菌可产生新型抗菌抗生素TAN-1057 A、B、C和D。对产生抗生素的细菌进行了表征，并将其命名为屈挠杆菌属PK-74和PK-176。这些抗生素对革兰氏阴性菌和革兰氏阳性菌具有活性，包括耐甲氧西林金黄色葡萄球菌。TAN-1057 A抑制大肠杆菌和金黄色葡萄球菌中的蛋白质生物合成。它对小鼠实验性耐甲氧西林金黄色葡萄球菌感染显示出优异的保护作用。
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