Veazey R S, DeMaria M, Chalifoux L V, Shvetz D E, Pauley D R, Knight H L, Rosenzweig M, Johnson R P, Desrosiers R C, Lackner A A
New England Regional Primate Research Center, Harvard Medical School, 1 Pine Hill Drive, Post Office Box 9102, Southborough, MA 01772, USA.
Science. 1998 Apr 17;280(5362):427-31. doi: 10.1126/science.280.5362.427.
Human and simian immunodeficiency virus (HIV and SIV) replicate optimally in activated memory CD4(+) T cells, a cell type that is abundant in the intestine. SIV infection of rhesus monkeys resulted in profound and selective depletion of CD4+ T cells in the intestine within days of infection, before any such changes in peripheral lymphoid tissues. The loss of CD4+ T cells in the intestine occurred coincident with productive infection of large numbers of mononuclear cells at this site. The intestine appears to be a major target for SIV replication and the major site of CD4+ T cell loss in early SIV infection.
人类和猿猴免疫缺陷病毒（HIV和SIV）在活化的记忆性CD4(+) T细胞中能实现最佳复制，这种细胞类型在肠道中大量存在。恒河猴感染SIV后，在感染数天内肠道中的CD4+ T细胞就出现了严重且选择性的耗竭，而外周淋巴组织在此之前并未出现任何此类变化。肠道中CD4+ T细胞的丧失与该部位大量单核细胞的活跃感染同时发生。肠道似乎是SIV复制的主要靶器官，也是早期SIV感染中CD4+ T细胞丧失的主要部位。
