• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Gastrointestinal germinal center B cell depletion and reduction in IgA plasma cells in HIV-1 infection.在 HIV-1 感染中，胃肠道生发中心 B 细胞耗竭和 IgA 浆细胞减少。
Sci Immunol. 2024 Oct 25;9(100):eado0090. doi: 10.1126/sciimmunol.ado0090.
2
Gastrointestinal germinal center B cell depletion and reduction in IgA plasma cells in HIV-1 infection.HIV-1感染中胃肠道生发中心B细胞耗竭及IgA浆细胞减少
bioRxiv. 2024 Oct 17:2024.05.17.590425. doi: 10.1101/2024.05.17.590425.
3
IgA-producing plasma cells originate from germinal centers that are induced by B-cell receptor engagement in humans.产生 IgA 的浆细胞来源于生发中心，生发中心由人类 B 细胞受体结合诱导产生。
Gastroenterology. 2011 Mar;140(3):947-56. doi: 10.1053/j.gastro.2010.12.005. Epub 2010 Dec 11.
4
Re-thinking the functions of IgA(+) plasma cells.重新思考 IgA(+) 浆细胞的功能。
Gut Microbes. 2014;5(5):652-62. doi: 10.4161/19490976.2014.969977.
5
Early T Follicular Helper Cell Responses and Germinal Center Reactions Are Associated with Viremia Control in Immunized Rhesus Macaques.早期 T 滤泡辅助细胞反应和生发中心反应与免疫恒河猴的病毒血症控制相关。
J Virol. 2019 Feb 5;93(4). doi: 10.1128/JVI.01687-18. Print 2019 Feb 15.
6
Gut Microbiome Homeostasis and the CD4 T- Follicular Helper Cell IgA Axis in Human Immunodeficiency Virus Infection.人类免疫缺陷病毒感染中的肠道微生物群稳态与CD4滤泡辅助性T细胞IgA轴
Front Immunol. 2021 Mar 19;12:657679. doi: 10.3389/fimmu.2021.657679. eCollection 2021.
7
Rapid Emergence of T Follicular Helper and Germinal Center B Cells Following Antiretroviral Therapy in Advanced HIV Disease.在晚期 HIV 疾病中，抗逆转录病毒治疗后滤泡辅助 T 细胞和生发中心 B 细胞迅速出现。
Front Immunol. 2021 Dec 1;12:752782. doi: 10.3389/fimmu.2021.752782. eCollection 2021.
8
Germinal centers B-cell reaction and T follicular helper cells in response to HIV-1 infection.HIV-1 感染中生发中心 B 细胞反应和滤泡辅助 T 细胞。
Curr Opin HIV AIDS. 2019 Jul;14(4):246-252. doi: 10.1097/COH.0000000000000557.
9
Default in plasma and intestinal IgA responses during acute infection by simian immunodeficiency virus.在感染猴免疫缺陷病毒期间，血浆和肠道 IgA 反应缺失。
Retrovirology. 2012 May 25;9:43. doi: 10.1186/1742-4690-9-43.
10
Activation of CXCR3 Tfh cells and B cells in lymph nodes during acute HIV-1 infection correlates with HIV-specific antibody development.急性HIV-1感染期间淋巴结中CXCR3辅助性滤泡T细胞和B细胞的激活与HIV特异性抗体的产生相关。
J Virol. 2025 Mar 18;99(3):e0153224. doi: 10.1128/jvi.01532-24. Epub 2025 Feb 11.

引用本文的文献

1
Mucosal immunity in acute HIV: a review of recent work.急性HIV感染中的黏膜免疫：近期研究综述
Curr Opin HIV AIDS. 2025 May 1;20(3):193-198. doi: 10.1097/COH.0000000000000917. Epub 2025 Jan 24.
2
The Impact of HIV on B Cell Compartment and Its Implications for COVID-19 Vaccinations in People with HIV.人类免疫缺陷病毒对B细胞区室的影响及其对HIV感染者新冠疫苗接种的意义
Vaccines (Basel). 2024 Dec 5;12(12):1372. doi: 10.3390/vaccines12121372.

本文引用的文献

1
Gut-associated lymphoid tissue attrition associates with response to anti-α4β7 therapy in ulcerative colitis.肠相关淋巴组织耗竭与溃疡性结肠炎对 α4β7 治疗的反应相关。
Sci Immunol. 2024 Apr 19;9(94):eadg7549. doi: 10.1126/sciimmunol.adg7549.
2
Beyond butyrate: microbial fiber metabolism supporting colonic epithelial homeostasis.除了丁酸盐：支持结肠上皮细胞稳态的微生物纤维代谢。
Trends Microbiol. 2024 Feb;32(2):178-189. doi: 10.1016/j.tim.2023.07.014. Epub 2023 Aug 16.
3
Reduced abundance of butyric acid-producing bacteria in the ileal mucosa-associated microbiota of ulcerative colitis patients.溃疡性结肠炎患者回肠黏膜相关微生物群中丁酸产生菌的丰度降低。
J Clin Biochem Nutr. 2023 Jul;73(1):77-83. doi: 10.3164/jcbn.22-86. Epub 2023 Apr 14.
4
Autoimmune diseases exhibit shared alterations in the gut microbiota.自身免疫性疾病表现出肠道微生物组的共同改变。
Rheumatology (Oxford). 2024 Mar 1;63(3):856-865. doi: 10.1093/rheumatology/kead364.
5
Butyrate producers, "The Sentinel of Gut": Their intestinal significance with and beyond butyrate, and prospective use as microbial therapeutics.丁酸盐产生菌，“肠道哨兵”：它们在肠道中的意义及其与丁酸盐的关联及其他方面，以及作为微生物疗法的潜在用途。
Front Microbiol. 2023 Jan 12;13:1103836. doi: 10.3389/fmicb.2022.1103836. eCollection 2022.
6
Continuous germinal center invasion contributes to the diversity of the immune response.持续的生发中心入侵有助于免疫反应的多样性。
Cell. 2023 Jan 5;186(1):147-161.e15. doi: 10.1016/j.cell.2022.11.032. Epub 2022 Dec 23.
7
The systemic anti-microbiota IgG repertoire can identify gut bacteria that translocate across gut barrier surfaces.系统抗微生物 IgG 谱可识别穿过肠道屏障表面的肠道细菌。
Sci Transl Med. 2022 Aug 17;14(658):eabl3927. doi: 10.1126/scitranslmed.abl3927.
8
Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies.诱导广泛中和抗体的 HIV-1 疫苗策略。
Nat Rev Immunol. 2023 Mar;23(3):142-158. doi: 10.1038/s41577-022-00753-w. Epub 2022 Aug 12.
9
Environmental factors shaping the gut microbiome in a Dutch population.塑造荷兰人群肠道微生物群的环境因素
Nature. 2022 Apr;604(7907):732-739. doi: 10.1038/s41586-022-04567-7. Epub 2022 Apr 13.
10
Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity.溃疡性结肠炎的特征是浆母细胞偏向的体液反应与疾病活动相关。
Nat Med. 2022 Apr;28(4):766-779. doi: 10.1038/s41591-022-01680-y. Epub 2022 Feb 21.

在 HIV-1 感染中，胃肠道生发中心 B 细胞耗竭和 IgA 浆细胞减少。

Gastrointestinal germinal center B cell depletion and reduction in IgA plasma cells in HIV-1 infection.

机构信息

Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

出版信息

Sci Immunol. 2024 Oct 25;9(100):eado0090. doi: 10.1126/sciimmunol.ado0090.

DOI:10.1126/sciimmunol.ado0090
PMID:39454027
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11557871/
Abstract

Gastrointestinal (GI) B cells and plasma cells (PCs) are critical to mucosal homeostasis and the host response to HIV-1 infection. Here, high-resolution mapping of human B cells and PCs sampled from the colon and ileum during both viremic and suppressed HIV-1 infection identified a reduction in germinal center (GC) B cells and follicular dendritic cells (FDCs) during HIV-1 viremia. Immunoglobulin A-positive (IgA) PCs are the major cellular output of intestinal GCs and were significantly reduced during viremic HIV-1 infection. PC-associated transcriptional perturbations, including type I interferon signaling, persisted in antiretroviral therapy (ART)-treated individuals, suggesting ongoing disruption of the intestinal immune milieu during ART. GI humoral immune perturbations were associated with changes in the intestinal microbiome composition and systemic inflammation. These findings highlight a key immune defect in the GI mucosa due to HIV-1 viremia.

摘要

胃肠道 (GI) B 细胞和浆细胞 (PCs) 对于黏膜稳态和宿主对 HIV-1 感染的反应至关重要。在这里，对病毒血症和抑制的 HIV-1 感染期间从结肠和回肠中取样的人类 B 细胞和 PCs 进行高分辨率绘图，确定在 HIV-1 病毒血症期间生发中心 (GC) B 细胞和滤泡树突状细胞 (FDC) 减少。免疫球蛋白 A 阳性 (IgA) PCs 是肠道 GCs 的主要细胞输出物，在病毒血症 HIV-1 感染期间显著减少。与 PC 相关的转录扰动，包括 I 型干扰素信号，在接受抗逆转录病毒治疗 (ART) 的个体中持续存在，这表明在 ART 期间肠道免疫环境持续受到破坏。GI 体液免疫扰动与肠道微生物组组成和全身炎症的变化有关。这些发现强调了由于 HIV-1 病毒血症导致的 GI 黏膜中的关键免疫缺陷。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a5b/11557871/39ffd1d08b3c/nihms-2032038-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a5b/11557871/b95568b59892/nihms-2032038-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a5b/11557871/3eeb7488b0b0/nihms-2032038-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a5b/11557871/557663ced59d/nihms-2032038-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a5b/11557871/62cf1d4f53bf/nihms-2032038-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a5b/11557871/eb62447b8e40/nihms-2032038-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a5b/11557871/1792fe871ae0/nihms-2032038-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a5b/11557871/39ffd1d08b3c/nihms-2032038-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a5b/11557871/b95568b59892/nihms-2032038-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a5b/11557871/3eeb7488b0b0/nihms-2032038-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a5b/11557871/557663ced59d/nihms-2032038-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a5b/11557871/62cf1d4f53bf/nihms-2032038-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a5b/11557871/eb62447b8e40/nihms-2032038-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a5b/11557871/1792fe871ae0/nihms-2032038-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a5b/11557871/39ffd1d08b3c/nihms-2032038-f0007.jpg