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Comparison of the human and murine ATRX gene identifies highly conserved, functionally important domains.

作者信息

Picketts D J, Tastan A O, Higgs D R, Gibbons R J

机构信息

MRC Molecular Haematology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, OX3 9DS, UK.

出版信息

Mamm Genome. 1998 May;9(5):400-3. doi: 10.1007/s003359900781.

DOI:10.1007/s003359900781
PMID:9545503
Abstract
摘要

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1
Comparison of the human and murine ATRX gene identifies highly conserved, functionally important domains.
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2
A novel transcription regulatory complex containing death domain-associated protein and the ATR-X syndrome protein.一种包含死亡结构域相关蛋白和ATR-X综合征蛋白的新型转录调节复合物。
J Biol Chem. 2004 May 7;279(19):20369-77. doi: 10.1074/jbc.M401321200. Epub 2004 Feb 27.
3
The human sex-reversing ATRX gene has a homologue on the marsupial Y chromosome, ATRY: implications for the evolution of mammalian sex determination.人类性别反转的ATRX基因在有袋类动物的Y染色体上有一个同源基因，即ATRY：对哺乳动物性别决定进化的启示。
Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13198-202. doi: 10.1073/pnas.230424497.
4
Mutations in transcriptional regulator ATRX establish the functional significance of a PHD-like domain.
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A conserved truncated isoform of the ATR-X syndrome protein lacking the SWI/SNF-homology domain.一种缺乏SWI/SNF同源结构域的ATR-X综合征蛋白的保守截短异构体。
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Prokaryotic members of a new family of putative helicases with similarity to transcription activator SNF2.与转录激活因子SNF2相似的假定解旋酶新家族的原核成员。
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ATRX encodes a novel member of the SNF2 family of proteins: mutations point to a common mechanism underlying the ATR-X syndrome.ATRX基因编码SNF2蛋白家族的一个新成员：突变表明ATRX综合征存在共同的潜在机制。
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Cloning and characterization of HARP/SMARCAL1: a prokaryotic HepA-related SNF2 helicase protein from human and mouse.HARP/SMARCAL1的克隆与特性分析：一种来自人和小鼠的原核生物中与甲型肝炎相关的SNF2解旋酶蛋白
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Cloning and mapping of SMARCA5 encoding hSNF2H, a novel human homologue of Drosophila ISWI.
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Dynamic Activity of Histone H3-Specific Chaperone Complexes in Oncogenesis.组蛋白H3特异性伴侣复合物在肿瘤发生中的动态活性
Front Oncol. 2022 Jan 11;11:806974. doi: 10.3389/fonc.2021.806974. eCollection 2021.
2
ATR-X syndrome: genetics, clinical spectrum, and management.ATR-X 综合征：遗传学、临床谱及管理。
Hum Genet. 2021 Dec;140(12):1625-1634. doi: 10.1007/s00439-021-02361-5. Epub 2021 Sep 15.
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The Multiple Facets of ATRX Protein.ATRX蛋白的多方面特性

本文引用的文献

1
Mutations in transcriptional regulator ATRX establish the functional significance of a PHD-like domain.
Nat Genet. 1997 Oct;17(2):146-8. doi: 10.1038/ng1097-146.
2
Determination of the genomic structure of the XNP/ATRX gene encoding a potential zinc finger helicase.编码一种潜在锌指解旋酶的XNP/ATRX基因的基因组结构测定。
Genomics. 1997 Jul 15;43(2):149-55. doi: 10.1006/geno.1997.4793.
3
Cloning, chromosomal mapping and expression pattern of the mouse Brca2 gene.小鼠Brca2基因的克隆、染色体定位及表达模式
Cancers (Basel). 2021 May 5;13(9):2211. doi: 10.3390/cancers13092211.
4
Neurodevelopmental Disorders Caused by Defective Chromatin Remodeling: Phenotypic Complexity Is Highlighted by a Review of ATRX Function.由染色质重塑缺陷引起的神经发育障碍：对ATRX功能的综述突显了表型复杂性
Front Genet. 2020 Aug 11;11:885. doi: 10.3389/fgene.2020.00885. eCollection 2020.
5
Molecular effects of dADD1 misexpression in chromatin organization and transcription.dADD1 表达失调对染色质结构和转录的分子影响。
BMC Mol Cell Biol. 2020 Mar 23;21(1):17. doi: 10.1186/s12860-020-00257-2.
6
Syndromic disorder of sex development due to a novel hemizygous mutation in the carboxyl-terminal domain of .由于[具体基因名称]羧基末端结构域中的一种新型半合子突变导致的性发育综合征性疾病 。 （原文中“of”后面缺少具体基因名称，以上是补充完整后的翻译，你可根据实际情况修改）
Hum Genome Var. 2017 Apr 13;4:17012. doi: 10.1038/hgv.2017.12. eCollection 2017.
7
Analysis of neonatal brain lacking ATRX or MeCP2 reveals changes in nucleosome density, CTCF binding and chromatin looping.对缺乏ATRX或MeCP2的新生儿大脑进行分析，发现核小体密度、CTCF结合和染色质环化发生了变化。
Nucleic Acids Res. 2014 Jul;42(13):8356-68. doi: 10.1093/nar/gku564. Epub 2014 Jul 2.
8
Loss of Atrx sensitizes cells to DNA damaging agents through p53-mediated death pathways.ATRX 缺失通过 p53 介导的死亡途径使细胞对 DNA 损伤剂敏感。
PLoS One. 2012;7(12):e52167. doi: 10.1371/journal.pone.0052167. Epub 2012 Dec 17.
9
Structure and Mechanisms of SF1 DNA Helicases.SF1 解旋酶的结构与机制。
Adv Exp Med Biol. 2013;767:17-46. doi: 10.1007/978-1-4614-5037-5_2.
10
Compromised genomic integrity impedes muscle growth after Atrx inactivation.基因组完整性受损会阻碍 Atrx 失活后肌肉的生长。
J Clin Invest. 2012 Dec;122(12):4412-23. doi: 10.1172/JCI63765. Epub 2012 Nov 1.
Hum Mol Genet. 1997 Feb;6(2):291-300. doi: 10.1093/hmg/6.2.291.
4
A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors.TIF1α和TIF1β可能参与核受体对转录的表观遗传调控。
EMBO J. 1996 Dec 2;15(23):6701-15.
5
ATRX encodes a novel member of the SNF2 family of proteins: mutations point to a common mechanism underlying the ATR-X syndrome.ATRX基因编码SNF2蛋白家族的一个新成员：突变表明ATRX综合征存在共同的潜在机制。
Hum Mol Genet. 1996 Dec;5(12):1899-907. doi: 10.1093/hmg/5.12.1899.
6
Molecular cloning and characterization of annexin V-binding proteins with highly hydrophilic peptide structure.具有高度亲水性肽结构的膜联蛋白V结合蛋白的分子克隆与特性分析
J Neurochem. 1996 Jul;67(1):89-97. doi: 10.1046/j.1471-4159.1996.67010089.x.
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Repression and activation by multiprotein complexes that alter chromatin structure.通过改变染色质结构的多蛋白复合物进行的抑制和激活。
Genes Dev. 1996 Apr 15;10(8):905-20. doi: 10.1101/gad.10.8.905.
8
Sequence of the murine factor VIII cDNA.小鼠凝血因子VIII cDNA序列。
Genomics. 1993 May;16(2):374-9. doi: 10.1006/geno.1993.1200.
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Cloning and expression of the murine homologue of a putative human X-linked nuclear protein gene closely linked to PGK1 in Xq13.3.与位于Xq13.3的磷酸甘油酸激酶1（PGK1）紧密连锁的一个假定的人类X连锁核蛋白基因的小鼠同源物的克隆与表达。
Hum Mol Genet. 1994 Jan;3(1):39-44. doi: 10.1093/hmg/3.1.39.
10
Contrasting effects of alpha and beta globin regulatory elements on chromatin structure may be related to their different chromosomal environments.α和β珠蛋白调控元件对染色质结构的不同影响可能与其不同的染色体环境有关。
EMBO J. 1995 Apr 18;14(8):1718-26. doi: 10.1002/j.1460-2075.1995.tb07161.x.