Biben C, Hatzistavrou T, Harvey R P
The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Melbourne, Victoria 3050, Australia.
Mech Dev. 1998 Apr;73(1):125-7. doi: 10.1016/s0925-4773(98)00037-9.
NK-2 class homeobox genes are candidate patterning and lineage regulators in diverse organisms. We report here the embryonic expression pattern of murine member, Nkx2-6. In keeping with its vertebrate relatives, Nkx2-6 was transcribed in ventrolateral embryonic structures. Expression was first detected at E8.0 in endodermal walls of the foregut pocket, tissue destined to become pharyngeal floor. From E8.0-10.5, transcripts were concentrated in pharyngeal pouches and juxtaposed arch ectoderm and mesoderm, as well as in more caudal gut segments. Expression was also seen at opposite poles of the developing heart from E8-8.5 in posterior myocardial progenitors, then sinus venosa and dorsal pericardium, and from E9.5 in outflow tract myocardium.
NK-2类同源框基因是多种生物中潜在的模式形成和谱系调节因子。我们在此报告小鼠成员Nkx2-6的胚胎表达模式。与它的脊椎动物亲属一致，Nkx2-6在前外侧胚胎结构中被转录。最早在胚胎第8.0天在前肠袋的内胚层壁中检测到表达，该组织将发育为咽底。从胚胎第8.0天到10.5天，转录本集中在咽囊、相邻的鳃弓外胚层和中胚层，以及更靠尾端的肠道节段。在胚胎第8天到8.5天，在心脏发育的相对两极，即后心肌祖细胞、然后是静脉窦和背侧心包中也观察到表达，从胚胎第9.5天开始在流出道心肌中表达。
