[GM1神经节苷脂贮积症基因敲除小鼠]
[GM1-gangliosidosis knockout mouse].
作者信息
Oshima A
机构信息
Department of Veterinary Science, National Institute of Infectious Disease, Tokyo.
出版信息
No To Hattatsu. 1998 Mar;30(2):148-51.
PMID:9545780
Abstract
We generated a beta-galactosidosis mouse by gene targeting in an embryonic stem cell. Clinical, pathological, and biochemical analyses revealed that this mouse is a useful animal model to study the pathogenesis and therapy of human GM1-gangliosidosis.
摘要
我们通过对胚胎干细胞进行基因靶向操作生成了一只β-半乳糖苷酶缺乏症小鼠。临床、病理和生化分析表明，这只小鼠是研究人类GM1神经节苷脂贮积症发病机制和治疗方法的有用动物模型。
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