Carlsson A, Petersson M, Twetman S
Public Dental Clinic, Vallås, Sweden.
Am J Dent. 1997 Jun;10(3):115-9.
To evaluate the clinical performance of Helioseal-F, a fluoride-containing fissure sealant, in school children at caries risk.
A caries risk assessment based on past caries experience, saliva microbial tests, buffer capacity and frequency of sugar intake was carried out in 204 healthy children, 6-7 years of age. Children exhibiting one or more risk factors were considered at caries risk (n = 121) and their permanent molars were sealed with a fluoride-containing fissure sealant, thus forming a fissure sealant group (FSG). The remaining 83 children with low caries risk received no fissure sealants and constituted a reference group (RG). Both groups were followed for 2 years. From 15 children of both groups, unstimulated whole saliva was collected 1 month after sealant placement in order to determine fluoride levels. In another 20 children, a split-mouth study design was utilized to compare the colonization of mutans streptococci adjacent to and on F-containing sealants and conventional controls. The sealants were placed by dental hygienists according to the manufacturers' instructions.
A total of 431 fissure sealants were placed at baseline. Complete retention was found in 76.6% during the study period while 22.0% were partially lost. Six sealants (1.4%) were completely lost. The enamel caries incidence was 45% lower (P < 0.05) in the permanent molars of the caries risk FSG compared with the low risk RG. There was no significant increase in saliva fluoride concentration following placement of the sealants and the proportion of mutans streptococci in relation to total viable counts was unaffected by type of material. The levels of salivary mutans streptococci were mainly unchanged in both groups during the study period, while the levels of salivary lactobacilli decreased in the FSG.
评估含氟窝沟封闭剂Helioseal - F在患龋风险儿童中的临床性能。
对204名6 - 7岁的健康儿童进行基于既往患龋经历、唾液微生物检测、缓冲能力和糖摄入频率的患龋风险评估。表现出一个或多个风险因素的儿童被视为患龋风险儿童（n = 121），其恒磨牙用含氟窝沟封闭剂进行封闭，从而形成窝沟封闭剂组（FSG）。其余83名患龋风险低的儿童未接受窝沟封闭剂，构成对照组（RG）。两组均随访2年。在两组的15名儿童中，窝沟封闭剂放置1个月后收集非刺激性全唾液以测定氟含量。在另外20名儿童中，采用半口研究设计比较含氟封闭剂及传统对照相邻部位和表面变形链球菌的定植情况。窝沟封闭剂由口腔保健员按照制造商说明放置。
基线时共放置了431颗窝沟封闭剂。在研究期间，76.6%的封闭剂完全保留，22.0%部分脱落。6颗封闭剂（1.4%）完全脱落。与低风险对照组相比，患龋风险窝沟封闭剂组恒磨牙的釉质龋发病率低45%（P < 0.05）。放置封闭剂后唾液氟浓度无显著增加，变形链球菌占总活菌数的比例不受材料类型影响。在研究期间，两组唾液变形链球菌水平基本未变，而窝沟封闭剂组唾液乳酸杆菌水平下降。
