De Diego J I, Prim M P, De Sarriá M J, Madero R, Gavilán J
Department of Otorhinolaryngology, La Paz Hospital, Autonomous University, Madrid, Spain.
Laryngoscope. 1998 Apr;108(4 Pt 1):573-5. doi: 10.1097/00005537-199804000-00020.
In a prospective, controlled, and randomized study, we compared the outcome of 101 Bell's palsy patients treated with acyclovir (54 patients) or prednisone (47 patients). The acyclovir dosage was 2400 mg (800 mg three times a day) for 10 days, and prednisone was given as a single daily dose of 1 mg/kg of body weight for 10 days and tapered to 0 over the next 6 days. Minimum follow-up was 3 months in all patients. Patients in the prednisone group had better clinical recovery than those treated with acyclovir. Less degree of neural degeneration was observed in the prednisone group compared with acyclovir patients. The incidence of sequelae was the same in both groups. According to these results, in a 10-day treatment cycle acyclovir given 800 mg three times is not as useful as prednisone given 1 mg/kg of body weight once a day in patients with idiopathic facial nerve paralysis.
在一项前瞻性、对照和随机研究中，我们比较了101例接受阿昔洛韦治疗（54例患者）或泼尼松治疗（47例患者）的贝尔麻痹患者的结局。阿昔洛韦剂量为2400毫克（每日三次，每次800毫克），持续10天，泼尼松每日单次剂量为1毫克/千克体重，持续10天，并在接下来的6天逐渐减至0。所有患者的最短随访时间为3个月。泼尼松组患者的临床恢复情况优于接受阿昔洛韦治疗的患者。与阿昔洛韦治疗的患者相比，泼尼松组观察到的神经变性程度较轻。两组的后遗症发生率相同。根据这些结果，在10天的治疗周期中，对于特发性面神经麻痹患者，每日三次给予800毫克阿昔洛韦不如每日一次给予1毫克/千克体重的泼尼松有效。
