Sato S, McCutchen C, Graham B, Freeman A, von Albertini-Carletti I, Alling D W
EEG Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892-1404, USA.
Electroencephalogr Clin Neurophysiol. 1997 Dec;103(6):627-32. doi: 10.1016/s0013-4694(97)00072-2.
'Sawtoothed' waves occur during rapid eye movement (REM) sleep, but their source as well as their function is not known. We studied the onset of sawtooth waves (STW) in relation to the onset of muscle tone reduction (MTR) and to REM during 20 polysomnographic recordings in 11 normal volunteers. Seventy-seven (85%) of a total of 91 REM sleep cycles were used for further analysis, because within a 1000 s interval they showed a relatively stereotyped sequence of events: a generalized body movement, followed by MTR, then the appearance of STW, and ending with the first REM. The first STW often occurred during the electrographic stage II period prior to the beginning of the REM, by which time muscle tone was either already at or close to the tone level of the REM sleep period in all subjects. The overall mean onset time of MTR was 267 s (range 89-660 s), STW was 378 s (range 169-779), and REM was 448 s (range 265-849); their differences were highly significant (F = 27.1, df 2,20, P < 0.001). Our data suggest that a predictable sequence of muscle tone reduction, then STW, and then REM, precedes the generally accepted onset of the REM sleep period, and may have implications for the redesignation of physiologic REM sleep onset.
“锯齿状”波出现在快速眼动（REM）睡眠期间，但其来源及功能尚不清楚。我们在11名正常志愿者的20次多导睡眠图记录中，研究了锯齿状波（STW）的起始与肌张力降低（MTR）起始以及REM的关系。总共91个REM睡眠周期中的77个（85%）用于进一步分析，因为在1000秒的间隔内，它们呈现出相对固定的事件序列：全身一般性运动，随后是MTR，接着是STW出现，最后以首次REM结束。首次STW通常出现在REM开始前的脑电图II期，此时所有受试者的肌张力已处于或接近REM睡眠期的肌张力水平。MTR的总体平均起始时间为267秒（范围89 - 660秒），STW为378秒（范围169 - 779秒），REM为448秒（范围265 - 849秒）；它们之间的差异具有高度显著性（F = 27.1，自由度2,20，P < 0.001）。我们的数据表明，在普遍认可的REM睡眠期起始之前，存在一个可预测的肌张力降低、然后是STW、再然后是REM的序列，这可能对重新定义生理性REM睡眠起始具有启示意义。
