Geisler P, Meier-Ewert K, Matsubayshi K
Neurological Hospital and Sleep Disorders Unit, Schwalmstadt-Treysa, F.R.G.
Electroencephalogr Clin Neurophysiol. 1987 Dec;67(6):499-507. doi: 10.1016/0013-4694(87)90051-4.
Seventeen unmedicated patients with narcolepsy-cataplexy and 17 age- and sex-matched controls were recorded polygraphically for 3 consecutive nights. Rapid eye movements (REMs), m. mentalis twitches and sawtooth waves in the EEG were visually scored. REM and twitch densities during REM sleep were significantly higher in the patients than in the controls. The distribution pattern of REMs and twitches was altered in the patients: twitch density peaked in the first REM period and density of REMs showed an even distribution across all the REM periods of the night. In the controls both REM and twitch density increased from the first to the second REM period. We therefore assume that in the narcoleptics phasic activity of REM sleep is disinhibited. Densities of REMs, twitches and sawtooth waves did not correlate with one another in patients and controls. They appear to be independently regulated. The REM periods of the patients contained 3 times as many waking epochs as those of the controls. This suggests that in narcolepsy the transition REM/waking is selectively facilitated. The REM/NREM ratio of twitch and sawtooth wave densities was the same in patients and controls.
对17名患有发作性睡病-猝倒症且未接受药物治疗的患者以及17名年龄和性别匹配的对照者进行了连续三晚的多导睡眠图记录。通过肉眼对脑电图中的快速眼动（REM）、颏肌抽搐和锯齿波进行评分。患者快速眼动睡眠期间的REM和抽搐密度显著高于对照者。患者的REM和抽搐分布模式发生了改变：抽搐密度在第一个REM期达到峰值，而REM密度在夜间所有REM期呈均匀分布。在对照者中，REM和抽搐密度从第一个REM期到第二个REM期均增加。因此，我们推测发作性睡病患者快速眼动睡眠的相位活动受到抑制。患者和对照者的REM、抽搐和锯齿波密度之间均无相关性。它们似乎是独立调节的。患者的REM期包含的觉醒时段是对照者的3倍。这表明在发作性睡病中，REM/觉醒的转换被选择性促进。患者和对照者的抽搐及锯齿波密度的REM/非快速眼动（NREM）比值相同。
