Roesler W J, Park E A
Department of Biochemistry, University of Saskatchewan, Saskatoon, Canada.
Mol Cell Biochem. 1998 Jan;178(1-2):1-8. doi: 10.1023/a:1006886421795.
The transcription rate of many genes, and particularly those which code for metabolically important proteins, is regulated by various hormones. Detailed analysis of the promoters of these genes has shown that, while functional 'Hormone response elements' exist, the hormonal responsiveness of many promoters is often synergistically mediated by several cis-elements, collectively referred to as a hormone response unit. The utilization of a hormone response unit to mediate a response offers several regulatory advantages, including an expansion of the range of transcriptional responses and modulation of the response by tissue- and developmental-specific cues. Furthermore, the presence of Hormone Response Units may provide a mechanism for the coordination of information from two or more signaling pathways into a single, integrated and exquisitely controlled transcriptional response. The protein-protein interactions that likely mediate many of the synergistic functional characteristics of Hormone Response Units may provide unique targets for therapeutic intervention.
许多基因，尤其是那些编码代谢重要蛋白质的基因的转录速率受多种激素调控。对这些基因启动子的详细分析表明，虽然存在功能性的“激素反应元件”，但许多启动子的激素反应性通常由几个顺式元件协同介导，这些顺式元件统称为激素反应单元。利用激素反应单元介导反应具有多种调控优势，包括扩大转录反应范围以及通过组织和发育特异性线索调节反应。此外，激素反应单元的存在可能为将来自两个或更多信号通路的信息协调成单一、整合且精确控制的转录反应提供一种机制。可能介导激素反应单元许多协同功能特性的蛋白质 - 蛋白质相互作用可能为治疗干预提供独特靶点。
