Kaul D, Kaur M, Dhawan V
Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Mol Cell Biochem. 1998 Jan;178(1-2):383-5. doi: 10.1023/a:1006853001631.
The present study provides evidence to support that human platelets possess a 47 kDa dual functional molecule having thiol-oxidase activity as well as high affinity for the SRE sequence in the human genome. On the basis of these as well as earlier results, we propose that Receptor 'Ck' dependent regulation of this dual functional 47 kDa molecule may provide a mechanism for the maintenance of cellular cholesterol homeostasis. Further, this mechanism may also explain the molecular basis of cholesterol-feedback lesion observed under premalignant conditions.
本研究提供了证据支持人类血小板拥有一种47 kDa的双功能分子，该分子具有硫醇氧化酶活性以及对人类基因组中SRE序列的高亲和力。基于这些以及早期的结果，我们提出受体“Ck”对这种双功能47 kDa分子的依赖性调节可能为维持细胞胆固醇稳态提供一种机制。此外，这种机制也可能解释在癌前状态下观察到的胆固醇反馈损伤的分子基础。
