Vitols S, Gahrton G, Björkholm M, Peterson C
Lancet. 1985 Nov 23;2(8465):1150-4. doi: 10.1016/s0140-6736(85)92679-0.
59 patients with acute leukaemia were examined to see if hypocholesterolaemia, which is commonly found in acute leukaemia, was due to the high low-density-lipoprotein (LDL)-receptor activity of leukaemic cells. LDL-receptor activity was found to be inversely correlated with plasma-cholesterol concentration. Patients with both a high LDL-receptor activity per cell and a high white-blood-cell count had the lowest cholesterol concentrations. During chemotherapy, cholesterol levels rose concomitantly with the disappearance from the peripheral blood of leukaemic cells. Hypocholesterolaemia in leukaemia and other neoplastic disorders may be due to increased LDL-receptor activity in the malignant cells. This high uptake and degradation of LDL by malignant cells could be utilised to target neoplastic cells with LDL-bound chemotherapeutic agents.
对59例急性白血病患者进行了检查，以确定急性白血病中常见的低胆固醇血症是否归因于白血病细胞的高低密度脂蛋白（LDL）受体活性。发现LDL受体活性与血浆胆固醇浓度呈负相关。每个细胞LDL受体活性高且白细胞计数高的患者胆固醇浓度最低。化疗期间，胆固醇水平随着白血病细胞从外周血中消失而同步升高。白血病和其他肿瘤性疾病中的低胆固醇血症可能是由于恶性细胞中LDL受体活性增加所致。恶性细胞对LDL的这种高摄取和降解可用于用与LDL结合的化疗药物靶向肿瘤细胞。
