Peng R, Wang D, Xiong C, Li Y, Gao Y, Wang B, Cui Y, Yang H, Hu W
J Environ Pathol Toxicol Oncol. 1998;17(2):129-33.
There have been only a few studies on the expression of c-kit in bone marrow after radiation and radiation-induced apoptosis of hematopoietic cells. LACA mice were examined after irradiation with a dose of 60Co gamma-rays. Using a light microscope, electron microscope, and immunohistochemistry, we studied radiation-induced apoptosis of hematopoietic cells and the expression of c-kit. We found that 5.5 Gy total body irradiation was a sublethal dose for LACA mice, induced suppression of leukocytes in blood, and of nucleated cells in bone marrow. Apoptosis of the hematopoietic cells occurred within 1 day after irradiation. The expression of c-kit was related to the recovery of hematopoiesis and played an important role in early hematopoiesis.
关于辐射后骨髓中c-kit的表达以及辐射诱导造血细胞凋亡的研究仅有少数。用60Coγ射线对LACA小鼠进行照射后进行检查。我们使用光学显微镜、电子显微镜和免疫组织化学方法，研究了辐射诱导的造血细胞凋亡以及c-kit的表达。我们发现，5.5 Gy全身照射对LACA小鼠是亚致死剂量，可导致血液中白细胞以及骨髓中有核细胞受到抑制。造血细胞凋亡在照射后1天内发生。c-kit的表达与造血恢复相关，并在早期造血中起重要作用。
