Bai Y, Wang D, Cui X, Yang Z, Zhu M, Zhang Z, Xia G, Gong Y
J Environ Pathol Toxicol Oncol. 1998;17(2):159-63.
We studied the early effects of selenium-enriched spiruline (SESP) on radiation-induced pulmonary fibrosis using histopathology, cDNA-mRNA dot-blot hybridization, and a biochemical technique for quantifying the hydroxyproline content. We found marked lung injury in the irradiated group, whereas only slight hyperemia, hemorrhage, exudation, and thickness of the interalveolar wall in the lung in the selenium-treated group. The hydroxyproline (hyp) content in the lungs and the synthesis of type III collagen mRNA decreased in the SESP-treated group. Selenium-enriched spiruline may have a protective effect on the development of radiation pneumonitis.
我们采用组织病理学、cDNA-mRNA斑点杂交以及定量羟脯氨酸含量的生化技术，研究了富硒螺旋藻（SESP）对辐射诱导的肺纤维化的早期影响。我们发现照射组有明显的肺损伤，而硒处理组的肺仅有轻微充血、出血、渗出以及肺泡壁增厚。富硒螺旋藻处理组肺中的羟脯氨酸（hyp）含量以及III型胶原mRNA的合成减少。富硒螺旋藻可能对放射性肺炎的发展具有保护作用。
