辐射性间质性肺炎中的胶原蛋白基因表达
Collagen gene expression in radiation interstitial pneumonitis.
作者信息
Bai Y H, Wang D W, Cui C B, Ci Y P, Cui X M, Xiong C Q, Zhang Z S, Liu B C
机构信息
Department of Experimental Pathology, Institute of Radiation Medicine, Beijing, China.
出版信息
J Environ Pathol Toxicol Oncol. 1994;13(4):231-4.
By using type I and type III collagen cDNA probe and cDNA-mRNA in situ hybridization, we observed the changes of rat lung alpha 1(I) and alpha 1(III) collagen gene expression in radiation interstitial pneumonitis. The results showed that the expressed cell of type I and type III collagen were scattered within the fibroblasts in the thickened interalveolar walls. The type I and type III collagen mRNA content in irradiated animals were higher than those in the controls at 0.5, 1, 2, 3, 6, and 12 months.
通过使用I型和III型胶原cDNA探针以及cDNA - mRNA原位杂交技术，我们观察了大鼠放射性间质性肺炎中肺α1(I)和α1(III)胶原基因表达的变化。结果显示，I型和III型胶原的表达细胞散在于增厚的肺泡间隔中的成纤维细胞内。在照射后0.5、1、2、3、6和12个月时，受照射动物的I型和III型胶原mRNA含量高于对照组。
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