肿瘤坏死因子α对血管内皮细胞上Fas配体表达的调节作用可调控白细胞渗出。
TNFalpha regulation of Fas ligand expression on the vascular endothelium modulates leukocyte extravasation.
作者信息
Sata M, Walsh K
机构信息
Division of Cardiovascular Research, St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA.
出版信息
Nat Med. 1998 Apr;4(4):415-20. doi: 10.1038/nm0498-415.
Abstract
It is generally believed that the vascular endothelium serves as an inflammatory barrier by providing a nonadherent surface to leukocytes. Here, we report that Fas ligand (FasL) is expressed on vascular endothelial cells (ECs) and that it may function to actively inhibit leukocyte extravasation. TNFalpha downregulates FasL expression with an accompanying decrease in EC cytotoxicity toward co-cultured Fas-bearing cells. Local administration of TNFalpha to arteries downregulates endothelial FasL expression and induces mononuclear cell infiltration. Constitutive FasL expression markedly attenuates TNFalpha-induced cell infiltration and adherent mononuclear cells undergo apoptosis under these conditions. These findings suggest that endothelial FasL expression can negatively regulate leukocyte extravasation.
摘要
一般认为，血管内皮通过为白细胞提供非黏附表面而作为一种炎症屏障。在此，我们报道Fas配体（FasL）在血管内皮细胞（ECs）上表达，并且它可能发挥积极抑制白细胞外渗的作用。肿瘤坏死因子α（TNFα）下调FasL表达，同时EC对共培养的携带Fas细胞的细胞毒性降低。向动脉局部给予TNFα可下调内皮FasL表达并诱导单核细胞浸润。组成性FasL表达显著减轻TNFα诱导的细胞浸润，并且在这些条件下黏附的单核细胞发生凋亡。这些发现提示内皮FasL表达可负向调节白细胞外渗。
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