Weinberger J
Cardiac Catheterization Laboratory, Columbia University, New York, NY 10032, USA.
Semin Interv Cardiol. 1997 Jun;2(2):103-8.
Intravascular irradiation by both gamma and beta sources has been shown to prevent neointimal proliferation after balloon injury in the overstretch pig coronary model. A number of clinical studies are underway that involve brachytherapy from gamma sources in vessels that have been stented. The purpose of this review is to analyse the physical nature of the interaction of various forms of radiation with stent materials and to summarize the available experimental information for relevant clinical correlates of these effects. The ultimate use of vascular radiation in the presence of metallic stents will require knowledge of the possible dose alterations, and where possible, techniques to compensate for these effects.
在过度扩张的猪冠状动脉模型中，已证明γ射线源和β射线源的血管内照射可预防球囊损伤后的内膜增生。目前正在进行多项临床研究，涉及对已植入支架的血管进行γ射线源近距离放射治疗。本综述的目的是分析各种形式的辐射与支架材料相互作用的物理性质，并总结有关这些效应的相关临床关联的现有实验信息。在存在金属支架的情况下最终使用血管内放射治疗将需要了解可能的剂量改变，并在可能的情况下了解补偿这些效应的技术。
