Hamidi Asl K, Liepnieks J J, Bihrle R, Benson M D
Department of Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis 46202-5251, USA.
Amyloid. 1998 Mar;5(1):49-54. doi: 10.3109/13506129809007290.
An amyloid tumor localized to the urethra was resected and shown by immunohistochemistry to contain fibril deposits that stained with antisera specific for lambda VI immunoglobulin light chain. The amino acid sequence of the fibril protein was homologous to lambda VI Positive staining of subepithelial plasma cells with lambda VI specific monoclonal antibody was consistent with the hypothesis that the fibril precursor light chain protein is synthesized and processed locally to give this type of localized amyloidosis.
一个局限于尿道的淀粉样瘤被切除，免疫组织化学显示其含有能被λVI免疫球蛋白轻链特异性抗血清染色的纤维沉积物。纤维蛋白的氨基酸序列与λVI同源。用λVI特异性单克隆抗体对上皮下浆细胞进行阳性染色，这与纤维前体轻链蛋白在局部合成和加工以产生这种类型的局限性淀粉样变性的假说一致。
