Kurt M A, Davies D C, Kidd M
Department of Anatomy and Developmental Biology, St. George's Hospital Medical School, Tooting, London, UK.
Neurosci Lett. 1997 Dec 12;239(1):41-4. doi: 10.1016/s0304-3940(97)00876-8.
Paired helical filaments (PHFs) are one of the hallmark pathologies of Alzheimer's disease (AD). PHFs occur in three intracellular locations, although hitherto, it was not known whether all PHFs are structurally homogeneous. Parietal cortex biopsies were taken from five patients with a clinical and histopathological diagnosis of AD and processed for electron microscopy. Photomicrographs were then taken of PHFs in neurofibrillary tangles (NFTs), neuropil threads (NTs) and neuritic plaque (NP) neurites and their dimensions measured. The mean half period, maximum and minimum widths of PHFs in NFTs were significantly smaller than those in NTs or NP neurites. The mean half period and maximum width of PHFs in NTs were similar to those in NP neurites. These results reveal the presence of two distinct PHF populations and investigation of their relationship may shed light on the pathogenesis of AD.
双螺旋丝（PHFs）是阿尔茨海默病（AD）的标志性病理特征之一。PHFs出现在三个细胞内位置，尽管迄今为止，尚不清楚所有的PHFs在结构上是否均一。从五名临床和组织病理学诊断为AD的患者身上获取顶叶皮质活检组织，并进行电子显微镜处理。然后拍摄神经原纤维缠结（NFTs）、神经毡丝（NTs）和神经炎性斑块（NP）神经突中的PHFs的显微照片，并测量其尺寸。NFTs中PHFs的平均半衰期、最大宽度和最小宽度明显小于NTs或NP神经突中的PHFs。NTs中PHFs的平均半衰期和最大宽度与NP神经突中的相似。这些结果揭示了存在两种不同的PHF群体，对它们之间关系的研究可能会为AD的发病机制提供线索。
