Inoue M, Yagishita S, Itoh Y, Amano N, Matsushita M
Division of Pathology, Kanagawa Rehabilitation Center, Japan.
Acta Neuropathol. 1996 Nov;92(5):511-4. doi: 10.1007/s004010050553.
The coexistence of polyglucosan bodies (PBs) and paired helical filaments (PHFs) in the same neuron is reported in an autopsy case of Alzheimer's disease. The patient was a 56-year-old Japanese male with a typical clinical course and pathological findings of Alzheimer's disease. Electron microscopically, numerous neurofibrillary tangles, mainly composed of PHFs, were observed in the neuronal cytoplasm, axons and dendrites. Some of them coexisted with other filamentous structures, which comprised randomly oriented branching filaments with a diameter of 5-10 nm. These structures were compatible with PBs. Glial tangles could not be found. Coexistence of these two structures was thought to occur in neurites.
在一例阿尔茨海默病尸检病例中，报告了同一神经元内多聚糖体（PBs）和双螺旋丝（PHFs）的共存情况。患者为一名56岁的日本男性，具有典型的阿尔茨海默病临床病程和病理表现。电子显微镜下，在神经元细胞质、轴突和树突中观察到大量主要由PHFs组成的神经原纤维缠结。其中一些与其他丝状结构共存，这些结构由直径为5 - 10 nm的随机取向分支丝组成。这些结构与PBs相符。未发现胶质缠结。这两种结构的共存被认为发生在神经突中。
