Andrykowski M A, Curran S L, Lightner R
Department of Behavioral Science, University of Kentucky College of Medicine, Lexington 40536-0086, USA.
J Behav Med. 1998 Feb;21(1):1-18. doi: 10.1023/a:1018700303959.
Fatigue is a common and distressing symptom following cancer treatment. Research examining "off-treatment" fatigue has been weakened by limited assessments of fatigue and lack of suitable comparison groups. The extent of off-treatment fatigue following treatment for breast cancer (BC) was examined. Women with BC (n = 88; mean, 28 months posttreatment) and age-matched women (n = 88) with benign breast problems (BBP), completed a set of fatigue questionnaires at an Initial assessment and a 4-month Follow-up assessment. The BC group reported more fatigue, more weakness, and less vitality relative to the BBP group at both assessments. No relationship was found in the BC group between fatigue and extent of treatment or time since treatment completion. While the results document the existence of off-treatment fatigue following BC, elucidation of the psychobiological processes underlying this symptom and development of clinical management strategies remain as challenges for future research.
疲劳是癌症治疗后常见且令人苦恼的症状。由于对疲劳的评估有限且缺乏合适的对照组，研究“治疗后”疲劳的研究受到了削弱。本研究考察了乳腺癌（BC）治疗后的治疗后疲劳程度。患有乳腺癌的女性（n = 88；平均，治疗后28个月）和年龄匹配的患有良性乳腺疾病（BBP）的女性（n = 88），在初始评估和4个月的随访评估中完成了一组疲劳问卷。在两次评估中，BC组相对于BBP组报告了更多的疲劳、更多的虚弱和更低的活力。在BC组中，未发现疲劳与治疗程度或治疗完成后的时间之间存在关联。虽然结果证明了BC治疗后存在治疗后疲劳，但阐明该症状背后的心理生物学过程以及制定临床管理策略仍然是未来研究的挑战。
