Kaufer D, Cummings J L, Christine D
Department of Neurology, University of California, Los Angeles School of Medicine, USA.
J Neuropsychiatry Clin Neurosci. 1998 Winter;10(1):55-63. doi: 10.1176/jnp.10.1.55.
Neuropsychiatric symptom responses to tacrine were investigated in an open-label study of Alzheimer's outpatients. Forty subjects were stratified into three groups (Mild, Moderate, and Severe) based on Mini-Mental State Examination scores. A significant reduction in total Neuropsychiatric Inventory score across all subjects was principally attributable to changes in the Moderate group. Apathy and disinhibition symptoms were significantly reduced overall. Whereas other symptoms showed differential responses in Mild and Severe subjects, all symptoms improved in Moderate subjects. These findings suggest that disease severity may significantly influence neuropsychiatric symptom responses to tacrine. Putative mechanisms underlying the observed pattern of responses are explored.
在一项针对阿尔茨海默病门诊患者的开放标签研究中，对他克林的神经精神症状反应进行了调查。根据简易精神状态检查表得分，40名受试者被分为三组（轻度、中度和重度）。所有受试者的神经精神症状总评分显著降低，这主要归因于中度组的变化。总体而言，淡漠和去抑制症状显著减轻。虽然其他症状在轻度和重度受试者中表现出不同的反应，但中度受试者的所有症状均有所改善。这些发现表明，疾病严重程度可能显著影响对他克林的神经精神症状反应。本文探讨了所观察到的反应模式背后的潜在机制。
