某些4-氨基-3-噌啉羧酸衍生物的合成与生物活性。第4部分：2,4-二氧代-1,2,3,4-四氢嘧啶并[5,4-c]噌啉。
Synthesis and biological activity of some 4-amino-3-cinnoline carboxylic acid derivatives. Part 4: 2,4-Dioxo-1,2,3,4-tetrahydropyrimido[5,4-c]cinnolines.
作者信息
Stańczak A, Lewgowd W, Pakulska W
机构信息
Department of Pharmaceutical Chemistry and Drug Analysis, Medical University Lódź, Poland.
出版信息
Pharmazie. 1998 Mar;53(3):156-61.
PMID:9547518
Abstract
A series of new 2,4-dioxo-1,2,3,4-tetrahydropyrimido[5,4-c]cinnolines and their 3-substituted derivatives were prepared. These compounds were obtained by cyclocondensation of the appropriate substituted 4-amino-3-cinnolinecarboxylic acid with urea or 4-amino-3-cinnolinecarboxamides with N,N'-carbonyldiimidazole (DCl), oxalyl chloride or diethyl carbonate. Most of these compounds showed a high sedative action in low doses.
摘要
制备了一系列新型的2,4-二氧代-1,2,3,4-四氢嘧啶并[5,4-c]喹啉及其3-取代衍生物。这些化合物是通过适当取代的4-氨基-3-喹啉羧酸与尿素环缩合，或4-氨基-3-喹啉甲酰胺与N,N'-羰基二咪唑（DCl）、草酰氯或碳酸二乙酯反应得到的。这些化合物中的大多数在低剂量时表现出高度的镇静作用。
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