Ono Y
Wakayama Prefecture Children and Disabled Persons' Counseling Center, Japan.
Res Dev Disabil. 1998 Mar-Apr;19(2):123-30. doi: 10.1016/s0891-4222(97)00046-2.
The behavior disorders of mentally retarded individuals receiving antipsychotic medication and the relationship between behavior disorders and the daily dose of drug were investigated. Of 355 residents of residential facilities in Wakayama Prefecture, Japan (age range, 7-64 years), the problem behaviors of 54 subjects receiving antipsychotic drugs were compared to those of 52 subjects receiving anticonvulsants and of 202 subjects without any medication at all, using the Japanese version of the Aberrant Behavior Checklist (ABC-J). All five subscale scores of the ABC-J were significantly higher for the antipsychotic group than for those of the other groups, whereas only the Irritability subscale was prominent in the subjects receiving anticonvulsants. The mean chlorpromazine equivalent dose was higher in the subjects with severe/profound disability than in those with mild/moderate disability and correlated with the Hyperactivity subscale scores. The problem behaviors of individuals with mental retardation prescribed antipsychotic drugs were more severe than those without medication; more severe disability and higher Hyperactivity scores were associated with dose of antipsychotic drugs.
对接受抗精神病药物治疗的智障人士的行为障碍以及行为障碍与药物日剂量之间的关系进行了调查。在日本和歌山县居住设施中的355名居民（年龄范围为7至64岁）中，使用日语版异常行为检查表（ABC-J），将54名接受抗精神病药物治疗的受试者的问题行为与52名接受抗惊厥药物治疗的受试者以及202名未接受任何药物治疗的受试者的问题行为进行了比较。抗精神病药物组的ABC-J所有五个子量表得分均显著高于其他组，而接受抗惊厥药物治疗的受试者中只有易激惹性子量表得分突出。重度/极重度残疾受试者的氯丙嗪等效剂量均值高于轻度/中度残疾受试者，且与多动性子量表得分相关。服用抗精神病药物的智障人士的问题行为比未服药者更严重；更严重的残疾和更高的多动得分与抗精神病药物剂量有关。
