Wressell S E, Tyrer S P, Berney T P
Fleming Nuffield Unit, Newcastle upon Tyne.
Br J Psychiatry. 1990 Jul;157:101-6. doi: 10.1192/bjp.157.1.101.
An investigation in a large mental handicap hospital revealed that 24% of the in-patients were receiving antipsychotic drugs. Chlorpromazine and thioridazine prescriptions accounted for 62% of the total while 10% of patients received depot preparations. Fifty-five per cent of the patients receiving these drugs had no established psychiatric diagnosis; most of these could be categorised as having a behaviour disorder. Patients aged 30-50 received higher doses, and female patients received a significantly higher mean dosage than male ones. In the patients receiving neuroleptic drugs who had also been taking them four years previously, there was a significant reduction in the dosage of the drugs received and the extent of polypharmacy of these agents. A mandatory requirement to review all prescriptions annually, implemented in 1984, may be a reason for this.
在一家大型智障医院进行的一项调查显示，24%的住院患者正在接受抗精神病药物治疗。氯丙嗪和硫利达嗪的处方占总数的62%，而10%的患者接受长效制剂。接受这些药物治疗的患者中，55%没有确诊的精神疾病诊断；其中大多数可归类为患有行为障碍。30至50岁的患者服用剂量更高，女性患者的平均剂量明显高于男性患者。在那些四年之前就一直在服用抗精神病药物的患者中，所接受药物的剂量以及这些药物的联合用药程度都有显著降低。1984年实施的每年对所有处方进行审查的强制要求可能是造成这种情况的一个原因。
