Garland M
Department of Pediatrics, College of Physicians and Surgeons, Columbia Univesity, New York, New York, USA.
Obstet Gynecol Clin North Am. 1998 Mar;25(1):21-42. doi: 10.1016/s0889-8545(05)70356-9.
The effect of drugs in the fetus can be thought of in terms of the dose-response based on a knowledge of the general principles by which drug is transferred from the mother to the fetus. Fetal drug concentration, which determines the fetal response, is a function of the maternal concentration, the placental permeability, the fetal drug clearance, and differences in protein binding and ionization between the maternal and fetal plasma.
基于药物从母体转移至胎儿的一般原理的知识，可从剂量反应的角度来考虑药物对胎儿的影响。决定胎儿反应的胎儿药物浓度，是母体浓度、胎盘通透性、胎儿药物清除率以及母体与胎儿血浆之间蛋白质结合和离子化差异的函数。
