Potential inhibitors of plasmodial heme oxygenase; an innovative approach for combating chloroquine resistant malaria.

Syntheses of imidazo-pyridines and substituted prolines and their effect on heme oxygenase activity of Plasmodium yoelii and corresponding infected host have been studied. Six compounds in vitro and one in vivo showed selective inhibition of parasite enzyme which may be further exploited in the development of resistant reversal agents.