Srivastava P, Pandey V C, Misra A P, Gupta P, Raj K, Bhaduri A P
Biochemistry Division, Central Drug Research Institute, Lucknow, India.
Bioorg Med Chem. 1998 Feb;6(2):181-7. doi: 10.1016/s0968-0896(97)10013-x.
Syntheses of imidazo-pyridines and substituted prolines and their effect on heme oxygenase activity of Plasmodium yoelii and corresponding infected host have been studied. Six compounds in vitro and one in vivo showed selective inhibition of parasite enzyme which may be further exploited in the development of resistant reversal agents.
对咪唑并吡啶和取代脯氨酸的合成及其对约氏疟原虫和相应感染宿主的血红素加氧酶活性的影响进行了研究。六种化合物在体外和一种化合物在体内显示出对寄生虫酶的选择性抑制作用，这在抗性逆转剂的开发中可能会得到进一步利用。
