一项比较甲泛葡胺和碘海醇用于马脊髓造影的前瞻性临床试验。

A prospective clinical trial comparing metrizamide and iohexol for equine myelography.

作者信息

Widmer W R, Blevins W E, Jakovljevic S, Levy M, Teclaw R F, Han C M, Hurd C D

机构信息

Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47906, USA.

出版信息

Vet Radiol Ultrasound. 1998 Mar-Apr;39(2):106-9. doi: 10.1111/j.1740-8261.1998.tb01974.x.

DOI:10.1111/j.1740-8261.1998.tb01974.x

PMID:9548136

Abstract

A prospective clinical trial comparing adverse postmyelographic effects and myelographic quality of metrizamide and iohexol was conducted. Using a predetermined, randomized assignment, 24 horses exhibiting neurologic signs were administered either metrizamide (180 mgl/ml) or iohexol (180 mgl/ml) via cerebellomedullary puncture. Each horse was evaluated postmyelographically for adverse effects. Myelographic quality was assessed by a numerical scoring method. Adverse effects were observed more frequently with metrizamide (21) compared with iohexol (6) myelography (p < 0.05). Seizures, intensification of preexisting neurologic signs and prolonged anesthetic recovery were the most common complications after myelography. There was no difference in myelographic quality (p > 0.05). We conclude that iohexol is safer than metrizamide for equine myelography and that quality myelograms can be obtained with either contrast medium.

摘要

进行了一项前瞻性临床试验，比较了甲泛葡胺和碘海醇的脊髓造影术后不良反应及脊髓造影质量。采用预先确定的随机分组方法，对24匹出现神经症状的马经小脑延髓穿刺给予甲泛葡胺（180mg/ml）或碘海醇（180mg/ml）。每匹马在脊髓造影术后评估不良反应。脊髓造影质量采用数字评分法评估。与碘海醇脊髓造影（6例）相比，甲泛葡胺脊髓造影（21例）观察到的不良反应更频繁（p<0.05）。癫痫发作、原有神经症状加重和麻醉恢复时间延长是脊髓造影后最常见的并发症。脊髓造影质量无差异（p>0.05）。我们得出结论，在马的脊髓造影中，碘海醇比甲泛葡胺更安全，两种造影剂均可获得高质量的脊髓造影图像。