Ilgin N, Iftehar S A, Vural G, Bozkirli I, Gokcora N
Department of Nuclear Medicine, Gazi University Medical School, Ankara, Turkey.
Nucl Med Commun. 1998 Feb;19(2):155-9. doi: 10.1097/00006231-199802000-00010.
The aim of this prospective study was to assess the efficacy of using whole-kidney, mean parenchymal and pelvic transit times to evaluate renal function following treatment with extracorporeal shock wave lithotripsy (ESWL). Fifteen patients were evaluated 24-48 h before and after ESWL therapy using 99Tcm-DTPA renal scintigraphy. Using deconvolution analysis, whole-kidney, mean parenchymal and pelvic transit times were calculated and the pre-ESWL values were compared with the post-ESWL values. In both kidneys, there were no significant changes in the glomerular filtration rate or relative renal uptake when compared with the pre-ESWL values. The mean whole-kidney transit time of the tracer did not change significantly during the post-ESWL period. In the treated kidney, the mean post-ESWL parenchymal transit time was significantly increased (P < 0.05), while the mean pelvic transit time was significantly decreased (P < 0.05). In the untreated kidney, there were no significant changes in any of these parameters. We conclude that the dual use of parenchymal and pelvic transit times is more sensitive than the mean whole-kidney transit time and other measures, such as glomerular filtration rate and relative renal uptake, for the assessment of outcome of therapy and other related post-ESWL changes.
这项前瞻性研究的目的是评估使用全肾、实质平均和肾盂通过时间来评估体外冲击波碎石术（ESWL）治疗后肾功能的疗效。在ESWL治疗前24 - 48小时和治疗后，使用99锝-二乙三胺五乙酸（99Tcm - DTPA）肾闪烁扫描对15名患者进行评估。采用去卷积分析计算全肾、实质平均和肾盂通过时间，并将ESWL治疗前的值与ESWL治疗后的值进行比较。与ESWL治疗前的值相比，双侧肾脏的肾小球滤过率或相对肾摄取均无显著变化。在ESWL治疗后的时间段内，示踪剂的平均全肾通过时间没有显著变化。在接受治疗的肾脏中，ESWL治疗后的实质平均通过时间显著增加（P < 0.05），而肾盂平均通过时间显著减少（P < 0.05）。在未接受治疗的肾脏中，这些参数均无显著变化。我们得出结论，对于评估治疗效果和其他ESWL相关的术后变化，实质和肾盂通过时间的双重使用比平均全肾通过时间以及其他测量指标（如肾小球滤过率和相对肾摄取）更敏感。
