Kleveland G, Engelsen B A
Institute of Neurology, University of Bergen, University Hospital, Haukeland sykehus, Norway.
Seizure. 1998 Feb;7(1):31-8. doi: 10.1016/s1059-1311(98)90005-x.
Forty-three patients with juvenile myoclonic epilepsy (JME) is presented. The female to male ratio was 2.9:1. The patients answered a standardized questionnaire pertaining to social situation, medical history, onset of epilepsy, types and frequency of seizures, treatment, experienced control over seizures and consequences of having epilepsy. Myoclonic jerks, which are the hallmark of the condition, are often forgotten by the patients or not considered as epileptic seizures. This could be one reason why JME still seems underdiagnosed. JME may comprise absence, myoclonic and generalized tonic-clonic seizures (GTCS), proposed to occur in age-related sequence. We found that absence seizures may start after onset of other seizures. Our results confirm the need for medication since, during the last year, only 7% were seizure free without medication. Of patients on antiepileptic drugs (AEDs), 79.5% had no GTCS and 41% were seizure free during the last year, which confirms a relatively good response to appropriate treatment. Although most patients used AED daily and many still had one or more types of epileptic seizure, the epilepsy in general had very little impact on their lives.
本文介绍了43例青少年肌阵挛性癫痫（JME）患者。男女比例为2.9:1。患者回答了一份关于社会状况、病史、癫痫发作起始、发作类型和频率、治疗、癫痫发作控制体验以及癫痫后果的标准化问卷。肌阵挛性抽搐是该病的标志，但患者常常会遗忘，或者不将其视为癫痫发作。这可能是JME似乎仍诊断不足的原因之一。JME可能包括失神发作、肌阵挛发作和全面性强直阵挛发作（GTCS），这些发作被认为按与年龄相关的顺序发生。我们发现失神发作可能在其他发作起始之后开始。我们的结果证实了药物治疗的必要性，因为在过去一年中，只有7%的患者在未用药的情况下无癫痫发作。在服用抗癫痫药物（AED）的患者中，79.5%在过去一年中没有发生GTCS，41%无癫痫发作，这证实了对适当治疗的反应相对良好。尽管大多数患者每天服用AED，而且许多患者仍有1种或更多类型的癫痫发作，但总体而言，癫痫对他们生活的影响很小。
