Jandhyala B S, Malloy K P, Buckley J P
Eur J Pharmacol. 1976 Jul;38(1):183-7. doi: 10.1016/0014-2999(76)90216-8.
I.v. administration of delta9-THC (2.5 mg/kg) To anesthetized dogs resulted in a decrease in heart rate, pulmonary blood flow (PBF), and a significant increase in pulmonary artery pressure (PAP) and total pulmonary vascular resistance (PVR). The increase in PVR to delta9-THC was significantly reduced by cardiac pacing, and was virtually abolished either by bilateral vagotomy or by pretreatment with hexamethonium. The data indicated the delta9-THC induced elevation of PVR was mediated via reflexogenic mechanisms involving afferent vagi and efferent autonomic pathways.
对麻醉犬静脉注射δ9-四氢大麻酚（2.5毫克/千克）导致心率、肺血流量（PBF）降低，肺动脉压（PAP）和总肺血管阻力（PVR）显著增加。通过心脏起搏，δ9-四氢大麻酚引起的PVR增加显著降低，双侧迷走神经切断术或六甲铵预处理几乎可消除这种增加。数据表明，δ9-四氢大麻酚诱导的PVR升高是通过涉及传入迷走神经和传出自主神经通路的反射机制介导的。
