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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Friedman E, Gershon S, Hine B, Torrelio M

Br J Pharmacol. 1977 Apr;59(4):561-3. doi: 10.1111/j.1476-5381.1977.tb07721.x.

Temporal effects of delta9-tetrahydrocannabinol (THC) on heart rate and blood pressure in conscious dogs were compared to those in anaesthetized dogs. 2. In conscious dogs, THC in doses of 0.25 and 0.1 mg/kg resulted in maximal heart rate reductions of 48 and 41%, respectively, and in no significant change in blood pressure. 3. In anaesthetized animals THC in doses of 0.5 and 0.25 mg/kg caused a peak reduction in heart rate of 38 and 34%, and of blood pressure of 24 and 8%, respectively. 4. The results demonstrate that the bradycardia in response to THC in dogs is independent of the concomitant anaesthesia. 5. We conclude that the discrepancy between heart rate response to THC in dogs and in man is due to a species difference.

将delta9 - 四氢大麻酚（THC）对清醒犬心率和血压的时间效应与麻醉犬进行了比较。2. 在清醒犬中，0.25和0.1 mg/kg剂量的THC分别导致心率最大降低48%和41%，血压无显著变化。3. 在麻醉动物中，0.5和0.25 mg/kg剂量的THC分别使心率峰值降低38%和34%，血压峰值降低24%和8%。4. 结果表明，犬对THC产生的心动过缓与伴随的麻醉无关。5. 我们得出结论，犬和人对THC心率反应的差异是由于物种差异。

Friedman E, Gershon S, Hine B, Torrelio M

Br J Pharmacol. 1977 Apr;59(4):561-3. doi: 10.1111/j.1476-5381.1977.tb07721.x.

Temporal effects of delta9-tetrahydrocannabinol (THC) on heart rate and blood pressure in conscious dogs were compared to those in anaesthetized dogs. 2. In conscious dogs, THC in doses of 0.25 and 0.1 mg/kg resulted in maximal heart rate reductions of 48 and 41%, respectively, and in no significant change in blood pressure. 3. In anaesthetized animals THC in doses of 0.5 and 0.25 mg/kg caused a peak reduction in heart rate of 38 and 34%, and of blood pressure of 24 and 8%, respectively. 4. The results demonstrate that the bradycardia in response to THC in dogs is independent of the concomitant anaesthesia. 5. We conclude that the discrepancy between heart rate response to THC in dogs and in man is due to a species difference.

将delta9 - 四氢大麻酚（THC）对清醒犬心率和血压的时间效应与麻醉犬进行了比较。2. 在清醒犬中，0.25和0.1 mg/kg剂量的THC分别导致心率最大降低48%和41%，血压无显著变化。3. 在麻醉动物中，0.5和0.25 mg/kg剂量的THC分别使心率峰值降低38%和34%，血压峰值降低24%和8%。4. 结果表明，犬对THC产生的心动过缓与伴随的麻醉无关。5. 我们得出结论，犬和人对THC心率反应的差异是由于物种差异。