局部麻醉药对离体灌注动脉对肾上腺素和去甲肾上腺素的血管收缩反应的影响。

The effect of local anaesthetics on the vasoconstrictor response of the isolated perfused artery to adrenaline and noradrenaline.

作者信息

Gerke D C, Frewin D B, Frost B R

出版信息

Eur J Pharmacol. 1976 Aug;38(2):243-52. doi: 10.1016/0014-2999(76)90326-5.

Abstract

The vascular response to intraluminally and extraluminally administered catecholamines mixed in combination with local anaesthetics has been studied using the isolated perfused rabbit ear artery as the model system. Potentiation of the vascular response to extraluminal adrenaline was observed when prilocaine, lignocaine or cocaine were combined in low concentrations with the vasoconstrictor. No potentiation of the vascular response to extraluminally administered noradrenaline could be demonstrated in the presence of prilocaine or lignocaine. Further, no potentiation to either catecholamine was found if the artery had been denervated or the drugs were applied intraluminally. Possible mechanisms for the potentiation of extraluminally applied adrenaline are discussed.

摘要

以离体灌注兔耳动脉作为模型系统，研究了与局部麻醉药混合后经腔内和腔外给药的儿茶酚胺的血管反应。当丙胺卡因、利多卡因或可卡因与血管收缩剂低浓度联合使用时，观察到对腔外肾上腺素的血管反应增强。在丙胺卡因或利多卡因存在的情况下，未证明对腔外给予去甲肾上腺素的血管反应增强。此外，如果动脉去神经或药物经腔内给药，则对任何一种儿茶酚胺均未发现增强作用。讨论了腔外应用肾上腺素增强作用的可能机制。