碘化钾诱导大鼠唾液腺鳞状细胞癌
Induction of squamous cell carcinomas in the salivary glands of rats by potassium iodide.
作者信息
Takegawa K, Mitsumori K, Onodera H, Yasuhara K, Kitaura K, Shimo T, Takahashi M
机构信息
Division of Pathology, National Institute of Health Sciences, Tokyo.
出版信息
Jpn J Cancer Res. 1998 Feb;89(2):105-9. doi: 10.1111/j.1349-7006.1998.tb00536.x.
Abstract
In a 2-year carcinogenicity study of potassium iodide (KI) in F344/DuCrj rats, squamous cell carcinomas (SCCs) were observed in the salivary glands of 4/40 males and 3/40 females receiving 1000 ppm KI in the drinking water. Ductular proliferation with lobular atrophy was observed at high incidence in the submandibular glands of the high-dose animals, and squamous metaplasia was frequently evident within the proliferative ductules and the larger interlobular ducts. A transition from metaplasia to SCC was apparent. The results suggest that squamous metaplasia in proliferative ductules, occurring secondarily to lobular impairment induced by KI, may develop into SCCs via a non-genotoxic, proliferation-dependent mechanism.
摘要
在一项对F344/DuCrj大鼠进行的为期两年的碘化钾（KI）致癌性研究中，饮用水中含有1000 ppm KI的40只雄性大鼠中有4只、40只雌性大鼠中有3只的唾液腺出现了鳞状细胞癌（SCC）。在高剂量动物的下颌下腺中，导管增生伴小叶萎缩的发生率很高，并且在增生的小导管和较大的小叶间导管内经常可见鳞状化生。化生向SCC的转变很明显。结果表明，由KI诱导的小叶损伤继发于增生性小导管中的鳞状化生，可能通过非基因毒性、增殖依赖性机制发展为SCC。
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本文引用的文献
1
SODIUM IODIDE-INDUCED SUBMAXILLARY SIALADENITIS IN THE RAT.碘化钠诱发大鼠颌下腺炎
Proc Soc Exp Biol Med. 1963 Nov;114:341-4. doi: 10.3181/00379727-114-28670.
2
3
Long-term toxicity/carcinogenicity study of L-histidine monohydrochloride in F344 rats.F344大鼠中L-盐酸组氨酸的长期毒性/致癌性研究
Food Chem Toxicol. 1996 Aug;34(8):687-91. doi: 10.1016/0278-6915(96)00033-6.
4
Squamous cell carcinoma of the breast: a clinical approach.乳腺鳞状细胞癌：一种临床处理方法。
Ann Surg Oncol. 1996 Jul;3(4):367-74. doi: 10.1007/BF02305666.
5
Growth pattern of experimental squamous cell carcinoma in rat submandibular glands--an immunohistochemical evaluation.大鼠下颌下腺实验性鳞状细胞癌的生长模式——免疫组织化学评估
Eur J Cancer B Oral Oncol. 1996 Mar;32B(2):97-105. doi: 10.1016/0964-1955(95)00080-1.
6
Induction of adenocarcinomas in the submandibular salivary glands of female Wistar rats treated with 7,12-dimethylbenz(a)anthracene.用7,12-二甲基苯并(a)蒽处理的雌性Wistar大鼠下颌下唾液腺腺癌的诱导
Arch Oral Biol. 1996 Feb;41(2):221-4. doi: 10.1016/0003-9969(95)00124-7.
7
Sialolithiasis. Differential diagnostic problems in fine-needle aspiration cytology.涎石病。细针穿刺细胞学检查中的鉴别诊断问题。
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8
P53 in squamous metaplasia: a marker for risk of respiratory tract carcinoma.鳞状化生中的P53：呼吸道癌风险的标志物
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9
10
Study on the carcinogenicity of tannic acid in F344 rats.
Food Chem Toxicol. 1994 Dec;32(12):1101-6. doi: 10.1016/0278-6915(94)90125-2.
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