三环类抗抑郁药和抗精神病药对利血平处理小鼠去甲肾上腺素外周及中枢作用的影响。

The effect of tricyclic antidepressants and neuroleptics on the peripheral and central action of norepinephrine in reserpine-treated mice.

作者信息

Nakamura M, Fukushima H

出版信息

Eur J Pharmacol. 1976 Aug;38(2):343-8. doi: 10.1016/0014-2999(76)90338-1.

Abstract

The effect of exogenous norepinephrine on the ptosis induced by reserpine and its modification by tricyclic antidepressants and neuroleptics were studied in reserpine-pretreated mice. S.c injection of norepinephrine (0.3-5 mg/kg) reversed dose-dependently the ptosis induced by reserpine. The maximal effect was obtained 15 min after norepinephrine administration. Tricyclic antidepressants (2.5 and 5 mg/kg i.p.) potentiated the effect of norepinephrine. In contrast neuroleptics (1 and 5 mg/kg i.p.) antagonized it. Intracerebral injection of norepinephrine (5-20 mug) also reversed dose-dependently the ptosis induced by reserpine, and the maximal effect was obtained within 5 min. Tricyclic antidepressants potentiated the effect of norepinephrine, but neuroleptics antagonized it. Among tricyclic antidepressants, the potentiating action of secondary amines was stronger than that of tertiary amines. Chlorpromazine blocked the action of norepinephrine more strongly than did the same dose of haloperidol.

摘要

在利血平预处理的小鼠中，研究了外源性去甲肾上腺素对利血平诱导的上睑下垂的影响以及三环类抗抑郁药和抗精神病药对其的修饰作用。皮下注射去甲肾上腺素（0.3 - 5mg/kg）可剂量依赖性地逆转利血平诱导的上睑下垂。给药后15分钟获得最大效应。三环类抗抑郁药（2.5和5mg/kg腹腔注射）增强了去甲肾上腺素的作用。相比之下，抗精神病药（1和5mg/kg腹腔注射）则拮抗其作用。脑室内注射去甲肾上腺素（5 - 20μg）也可剂量依赖性地逆转利血平诱导的上睑下垂，且在5分钟内获得最大效应。三环类抗抑郁药增强了去甲肾上腺素的作用，但抗精神病药拮抗其作用。在三环类抗抑郁药中，仲胺的增强作用强于叔胺。氯丙嗪比相同剂量的氟哌啶醇更强烈地阻断去甲肾上腺素的作用。