Cichy J, Rose-John S, Potempa J, Pryjma J, Travis J
Department of Microbiology and Immunology, Institute of Molecular Biology, Jagiellonian University, Krakow, Poland.
J Immunol. 1997 Dec 1;159(11):5648-53.
Soluble IL-6R (sIL-6R), which lacks the transmembrane domain, has been suggested to be a potent immunomodulator of IL-6 biologic activity. In this study, the ability of cells of hepatic origin to generate the sIL-6R was investigated. It was found that oncostatin M alone or in combination with the glucocorticoid analogue dexamethasone significantly up-regulated IL-6R release. Oncostatin M appeared to generate the sIL-6R primarily through an alternative splicing mechanism. Since sIL-6R is able to form biologically active complexes with IL-6, the release of the sIL-6R from hepatocytes may be important to sensitize cells lacking the membrane-bound receptor, particularly during an acute phase reaction.
可溶性白细胞介素-6受体（sIL-6R）缺乏跨膜结构域，被认为是白细胞介素-6生物活性的一种强效免疫调节剂。在本研究中，对肝源性细胞产生sIL-6R的能力进行了研究。发现单独使用抑瘤素M或与糖皮质激素类似物地塞米松联合使用时，可显著上调白细胞介素-6受体的释放。抑瘤素M似乎主要通过一种可变剪接机制产生sIL-6R。由于sIL-6R能够与白细胞介素-6形成生物活性复合物，肝细胞释放sIL-6R对于使缺乏膜结合受体的细胞敏感化可能很重要，尤其是在急性期反应期间。
