Furuya N, Kawano K, Shimazu H
Exp Brain Res. 1976 Jul 28;25(I):447-63. doi: 10.1007/BF00239780.
In decerebrate, unanesthetized cats, the brain stem was longitudinally cut at the midline from its dorsal to ventral surface with the cerebellum kept intact, eliminating neural interactions between the bilateral vestibular nuclei through the brain stem. Extracellular spike potentials of vestibular type I neurons identified by horizontal rotation were distinctly inhibited by contralateral vestibular nerve stimulation. This crossed inhibition was abolished by removal of the medial part of the cerebellum, indicating that the inhibition was mediated through the cerebellum. Neither aspiration of the flocculus on the recording side nor intravenous administration of picrotoxin eliminated transcerebellar crossed inhibition, suggesting that it is mediated through the cerebellar nuclei. When the fastigial, interposite and dentate nuclei were stimulated, inhibition of vestibular type I neurons was produced only from the contralateral fastigal nucleus. Cerebellocortical stimulation which inhibited fastigial type I neurons suppressed transcerebellar crossed inhibition. Effective sites for suppression of transcerebellar crossed inhibition were localized to lobules VI and VIIa in the vermal cortex on the side of labyrinthine stimulation. Intracellular recordings were made from type I neurons in the medial vestibular nucleus. Stimulation of the contralateral vestibular nerve and the contralateral fastigial nucleus produced IPSPs in these neurons with the shortest latency of 3.8 msec and 1.8 msec, respectively. The difference between these two latency values approximates the shortest latency of spike initiation of fastigial type I neurons in response to vestibular nerve stimulation. It is postulated that transcerebellar crossed inhibition is mediated through the fastigial nucleus on the side of labyrinthine stimulation.
在去大脑、未麻醉的猫中，将脑干从背侧至腹侧沿中线纵向切断，同时保持小脑完整，从而消除双侧前庭核之间通过脑干的神经相互作用。通过水平旋转确定的前庭I型神经元的细胞外锋电位受到对侧前庭神经刺激的明显抑制。切除小脑内侧部分后，这种交叉抑制被消除，表明这种抑制是通过小脑介导的。无论是记录侧绒球的吸出还是静脉注射印防己毒素都不能消除经小脑的交叉抑制，这表明它是通过小脑核介导的。当刺激顶核、间位核和齿状核时，仅对侧顶核产生前庭I型神经元的抑制。抑制顶核I型神经元的小脑皮质刺激抑制了经小脑的交叉抑制。抑制经小脑交叉抑制的有效部位定位于迷路刺激侧蚓部皮质的VI和VIIa小叶。对内侧前庭核的I型神经元进行细胞内记录。刺激对侧前庭神经和对侧顶核分别在这些神经元中产生IPSP，最短潜伏期分别为3.8毫秒和1.8毫秒。这两个潜伏期值之间的差异近似于顶核I型神经元对前庭神经刺激的锋电位起始最短潜伏期。据推测，经小脑交叉抑制是通过迷路刺激侧的顶核介导的。
