Tachibana K, Tachibana S
First Department of Anatomy, Fukuoka University School of Medicine.
Nihon Rinsho. 1998 Mar;56(3):584-8.
Ultrasound is frequently used in medicine for diagnostic purposes. Recently, there have been numerous reports on application of ultrasound energy for controlling drug release or targeting. This new concept of therapeutic ultrasound combined with drugs has induced excitement in various areas. Ultrasound energy can enhance effects of thrombolytic agents as urokinase. Ultrasound emitting catheters are currently being developed for cardiovascular diseases. Device with ultrasound transducers implanted in transdermal drug patches are also being evaluated for possible delivery of insulin through the skin. Chemical activation of drugs by ultrasound energy for treatment of cancers is another new field recently termed as "Sonodynamic Therapy". Various examples of application of ultrasound for drug delivery systems are discussed.
超声在医学中常用于诊断目的。最近，有许多关于应用超声能量来控制药物释放或靶向给药的报道。这种治疗性超声与药物相结合的新概念在各个领域引起了关注。超声能量可以增强尿激酶等溶栓剂的效果。目前正在研发用于心血管疾病的超声发射导管。植入透皮给药贴片中的超声换能器装置也正在评估其通过皮肤递送胰岛素的可能性。通过超声能量对药物进行化学活化以治疗癌症是另一个最近被称为“声动力疗法”的新领域。本文讨论了超声在药物递送系统中的各种应用实例。
