Yamasaki Y
First Dept. of Med., Osaka University School of Med.
Nihon Rinsho. 1998 Mar;56(3):748-51.
Long-term intensified insulin therapy composing of multiple insulin injection and self-blood glucose monitoring enables glycemic control of insulin-requiring diabetics. For reducing inconvenience of this therapy, several delivery route of insulin are under investigation. Nasal administration of insulin aerosol effectively controlled insulin-dependent diabetics for up to 6 months because its high bioavailability and rapid absorption. By means of ionophoresis or ultrasound approach, insulin was shown to be absorbed transdermally. Polymer containing modified insulin and immobilized enzyme could increase insulin release against hyperglycemia. These new approach of insulin delivery might increase convenience of insulin administration.
由多次胰岛素注射和自我血糖监测组成的长期强化胰岛素治疗能够使需要胰岛素治疗的糖尿病患者实现血糖控制。为了减少这种治疗的不便之处，目前正在研究多种胰岛素给药途径。鼻内给予胰岛素气雾剂可有效控制胰岛素依赖型糖尿病患者长达6个月，因为其生物利用度高且吸收迅速。通过离子电渗法或超声方法，胰岛素可经皮吸收。含有修饰胰岛素和固定化酶的聚合物能够在血糖升高时增加胰岛素释放。这些新的胰岛素给药途径可能会增加胰岛素给药的便利性。
