Maesaki S, Kohno S
Second Department of Internal Medicine, Nagasaki University School of Medicine.
Nihon Rinsho. 1998 Mar;56(3):752-61.
Various types of antimicrobial agents have been evolved to inhibit growth of or to kill different microorganisms. In recent years, encapsulation of antimicrobial agents in lipid formulations has been a popular practice in research work related to drug delivery system, although most of the studies are based primary on animal models. The recent developments of lipid formulations of anti-infectious drug (antibiotics, antifungals, and antiviral agents) with longer half-life opens new therapeutic avenues in treating infections. The passive targeting of liposomes to the sites of infection is of great value with respect to clinical application. Liposome entrapment can exchange their pharmacokinetics and, hence reduce their toxicity.
已经研发出各种类型的抗菌剂来抑制不同微生物的生长或杀死它们。近年来,在与药物递送系统相关的研究工作中,将抗菌剂包裹在脂质制剂中已成为一种普遍做法,尽管大多数研究主要基于动物模型。具有更长半衰期的抗感染药物(抗生素、抗真菌剂和抗病毒剂)脂质制剂的最新进展为治疗感染开辟了新的治疗途径。就临床应用而言,脂质体对感染部位的被动靶向具有重要价值。脂质体包封可以改变它们的药代动力学,从而降低它们的毒性。