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大鼠静脉注射辅酶A后肝脏和大脑中辅酶A的含量

Hepatic and cerebral coenzyme A contents after intravenous injection of coenzyme A in rats.

作者信息

Thölen H, Mordhorst R

出版信息

Experientia. 1976;32(7):830-2. doi: 10.1007/BF02003711.

DOI:10.1007/BF02003711
PMID:954956
Abstract

Hepatic CoA concentrations and contents were significantly higher in rats having received i.v. CoA injections that in control rats. Maximum hepatic CoA concentrations were found 0.5-1 h after injection. In rat brain, no increase in CoA concentration was detected after i.v. injection of CoA.

摘要

静脉注射辅酶A的大鼠肝脏中辅酶A的浓度和含量显著高于对照大鼠。注射后0.5 - 1小时可发现肝脏中辅酶A浓度达到最高值。在大鼠脑中，静脉注射辅酶A后未检测到辅酶A浓度升高。

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本文引用的文献

1
[Animal experimental and biochemical studies on the cause of increased enzyme activity in the blood in liver diseases].[关于肝脏疾病时血液中酶活性增加原因的动物实验及生化研究]
Z Gesamte Exp Med. 1959;132:346-58.
2
Effect of lipoic acid on the normal rat liver.
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3
Variations in tissue contents of coenzyme A thio esters and possible metabolic implications.辅酶A硫酯的组织含量变化及其可能的代谢意义。
Biochem J. 1964 Dec;93(3):550-7. doi: 10.1042/bj0930550.
4
[Brain edema. A cause of death in endogenous hepatic coma].[脑水肿。内源性肝昏迷的一个死因]
Klin Wochenschr. 1972 Mar 15;50(6):296-301. doi: 10.1007/BF01485177.
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Permeation of coenzyme A into liver cells.辅酶A渗透进入肝细胞。
Int J Clin Pharmacol. 1974 Oct;10(3):183-9.
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The leakage and destruction of CoA in isolated mitochondria.
Eur J Biochem. 1972 Jan 31;25(1):190-7. doi: 10.1111/j.1432-1033.1972.tb01684.x.
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Permeation of nucleotidic coenzymes into liver cells.核苷酸辅酶渗透进入肝细胞。
Int J Clin Pharmacol. 1974 Sep;10(2):101-10.
8
Changes in the concentrations of hepatic metabolites on administration of dihydroxyacetone or glycerol to starved rats and their relationship to the control of ketogenesis.给饥饿大鼠注射二羟基丙酮或甘油后肝脏代谢物浓度的变化及其与酮体生成调控的关系。
Biochem J. 1969 Sep;114(3):575-84. doi: 10.1042/bj1140575.