Lipolytic response of "diabetic" mice (db/db) to isoproterenol and propranolol in vivo.

The genetically diabetic and obese db/db mice responded lipolytically to isoproterenol and propranolol similarly to normal mice in vivo. However, considering the large amount of triglyceride in a db/db mouse, we conclude that the in vivo response of db/db adipose tissue is deficient in magnitude.