Bullmore E T, Woodruff P W, Wright I C, Rabe-Hesketh S, Howard R J, Shuriquie N, Murray R M
Department of Psychological Medicine and Biostatistics, Institute of Psychiatry, De Crespigny Park, London, UK.
Schizophr Res. 1998 Mar 10;30(2):127-35. doi: 10.1016/s0920-9964(97)00141-2.
Evidence is reviewed that dysplastic brain development in the second half of pregnancy predisposes to schizophrenia. We suggest that an important corollary of aberrant development at this stage of ontogenesis is abnormal afferentation of the cortical plate, and that this may be macroscopically measurable in terms of abnormal correlational structure in adult brain imaging data. This prediction is tested by analysis of multiple cortical volume measures on magnetic resonance imaging data acquired from 35 male right-handed schizophrenics and 35 matched controls. There are no significant differences between groups in global, intra-hemispheric or inter-hemispheric correlational structure; but schizophrenics are shown to have significantly reduced dependencies between frontal and temporal lobe volumes, and frontal and hippocampal volumes, in the left hemisphere. We conclude that anatomical dysconnectivity (between frontal and temporal cortex) in schizophrenia may be caused by dysplasia.
有证据表明，孕期后半段发育异常的大脑易患精神分裂症。我们认为，个体发育这一阶段发育异常的一个重要推论是皮质板传入异常，并且这在宏观上可能可通过成人脑成像数据中的异常相关结构来测量。通过对从35名右利手男性精神分裂症患者和35名匹配对照获取的磁共振成像数据进行多个皮质体积测量分析，对这一预测进行了检验。在整体、半球内或半球间相关结构上，两组之间没有显著差异；但结果显示，精神分裂症患者左半球额叶与颞叶体积之间以及额叶与海马体体积之间的相关性显著降低。我们得出结论，精神分裂症中的解剖学连接障碍（额叶与颞叶皮质之间）可能由发育异常引起。
