Matorras R, Rodríguez F, Gutierrez de Terán G, Pijoan J I, Ramón O, Rodríguez-Escudero F J
Department of Obstetrics and Gynecology, Hospital of Cruces-Baracaldo, País Vasco University, Vizcaya, Spain.
Eur J Obstet Gynecol Reprod Biol. 1998 Mar;77(1):101-5. doi: 10.1016/s0301-2115(97)00181-4.
To ascertain if there is an association between endometriosis and spontaneous abortion.
Prospective cohort study.
Medical School Hospital.
174 infertile women laparoscopically diagnosed with endometriosis and 174 infertile women in which endometriosis was ruled out by laparoscopy, in the same period of time.
Spontaneous abortion. Non-progressive gestational sac and/or histological study.
Per woman abortion rate was 7.47% (13/174) in the endometriosis group, similar to 5.74% (10/174) in the infertile women without endometriosis (RR=1.32: CI=0.53-3.36). Nor were there any differences in the per pregnancy abortion rate: 20.96% (13/62) in endometriosis vs. 16.94% (10/59) in non-endometriosis (RR=1.3; CI=0.47-3.57). The abortion rate was similar in the different AFS stages: 22.86% (8/35) in stage I, 16.67% (3/18) in II, 25% (1/4) in III and 20% (1/5) in IV. In stage I no differences were observed in patients who were managed expectantly or with medical treatment.
Endometriosis is not associated with an increased abortion rate. The severity of disease expressed by AFS staging is not associated with an increase in the abortion rate. In stage I the treatment of endometriosis did not decrease abortion rates.
确定子宫内膜异位症与自然流产之间是否存在关联。
前瞻性队列研究。
医学院附属医院。
174例经腹腔镜诊断为子宫内膜异位症的不孕女性以及同期174例经腹腔镜排除子宫内膜异位症的不孕女性。
自然流产。非进展性妊娠囊和/或组织学研究。
子宫内膜异位症组每位女性的流产率为7.47%（13/174），与无子宫内膜异位症的不孕女性的5.74%（10/174）相似（相对危险度=1.32：可信区间=0.53 - 3.36）。每次妊娠的流产率也无差异：子宫内膜异位症组为20.96%（13/62），非子宫内膜异位症组为16.94%（10/59）（相对危险度=1.3；可信区间=0.47 - 3.57）。不同美国生育学会（AFS）分期的流产率相似：I期为22.86%（8/35），II期为16.67%（3/18），III期为25%（1/4），IV期为20%（1/5）。在I期，期待治疗或药物治疗的患者未观察到差异。
子宫内膜异位症与流产率升高无关。AFS分期所表示的疾病严重程度与流产率升高无关。在I期，子宫内膜异位症的治疗并未降低流产率。
