Tomaszewski M M, Lupton G P
Department of Dermatopathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA.
J Cutan Pathol. 1998 Mar;25(3):129-35. doi: 10.1111/j.1600-0560.1998.tb01704.x.
Twenty-nine cases of histiocytic neoplasms, some resembling juvenile xanthogranuloma (JXG) and others resembling reticulohistiocytoma (RH), were evaluated. Immunohistochemical stains were performed. In this series, seven cases were identified that expressed S-100 protein positive cells. The S-100 positive cells were predominantly large mononuclear and multinucleated histiocytes with eosinophilic cytoplasm, but also in some cases xanthomatous cells and Touton giant cells. These cells also expressed a positive reaction for vimentin, KP-1, and Factor XIIIa. There was no reactivity observed for monoclonal antibody 010(CD1a). A positive reaction for S-100 protein is conventionally accepted as a useful differentiating feature between histiocytosis X and non-X histiocytosis such as JXG and RH. The conflicting results of the immunohistochemical stains in the lesions we studied could be potential pitfalls in diagnosing histiocytic neoplasms.
对29例组织细胞肿瘤进行了评估，其中一些类似幼年性黄色肉芽肿（JXG），另一些类似网状组织细胞瘤（RH）。进行了免疫组织化学染色。在该系列中，鉴定出7例表达S-100蛋白阳性细胞。S-100阳性细胞主要是具有嗜酸性细胞质的大单核和多核组织细胞，但在某些情况下也有黄色瘤细胞和 Touton 巨细胞。这些细胞对波形蛋白、KP-1和因子 XIIIa也呈阳性反应。未观察到单克隆抗体010（CD1a）的反应性。S-100蛋白阳性反应通常被认为是组织细胞增多症X与非X组织细胞增多症（如JXG和RH）之间有用的鉴别特征。我们研究的病变中免疫组织化学染色的矛盾结果可能是诊断组织细胞肿瘤的潜在陷阱。
