Khumalo H, Gomo Z A, Moyo V M, Gordeuk V R, Saungweme T, Rouault T A, Gangaidzo I T
Department of Medicine, University of Zimbabwe Medical School, Harare.
Clin Chem. 1998 Jan;44(1):40-4.
To test the hypothesis that the quantities of circulating transferrin receptors are reduced in iron overload, we studied serum transferrin receptors and indirect measures of iron status in 150 subjects from rural Zimbabwe. We found significant inverse correlations between serum concentrations of transferrin receptors and ferritin, the ratio of ferritin to aspartate aminotransferase, and transferrin saturation (r > or = 0.44; P < 0.001). The mean +/- SD concentration of serum transferrin receptors in 23 subjects classified as having iron overload (ferritin > 300 microg/L and transferrin saturation > 60%) was 1.55 +/- 0.61 mg/L, significantly lower than the 2.50 +/- 0.62 mg/L in 75 subjects with normal iron stores (ferritin 20-300 microg/L and transferrin saturation 15-55%; P < 0.0005) and the 2.83 +/- 1.14 mg/L in 8 subjects with iron deficiency (ferritin < 20 microg/L; P = 0.001). In keeping with the regulation of transferrin receptor expression at the cellular level, our findings suggest that serum transferrin receptors are decreased in the presence of iron overload.
为了验证铁过载时循环转铁蛋白受体数量会减少这一假说，我们研究了来自津巴布韦农村地区的150名受试者的血清转铁蛋白受体及铁状态的间接指标。我们发现，血清转铁蛋白受体浓度与铁蛋白、铁蛋白与天冬氨酸转氨酶的比值以及转铁蛋白饱和度之间存在显著的负相关（r≥0.44；P<0.001）。在23名被归类为铁过载（铁蛋白>300μg/L且转铁蛋白饱和度>60%）的受试者中，血清转铁蛋白受体的平均±标准差浓度为1.55±0.61mg/L，显著低于75名铁储备正常（铁蛋白20 - 300μg/L且转铁蛋白饱和度15 - 55%）受试者的2.50±0.62mg/L（P<0.0005），也低于8名缺铁（铁蛋白<20μg/L）受试者的2.83±1.14mg/L（P = 0.001）。与细胞水平上转铁蛋白受体表达的调控一致，我们的研究结果表明，在存在铁过载的情况下血清转铁蛋白受体会减少。
